Soja Plus

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Alekel, D.L., Germain, A.S., et al.: "Isoflavone-rich soy protein isolate attentuates bone loss in the lumbar spine of perimenopausal women". Am. J. Clin. Nutr. 2000; 72(3):844-52.

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Anthony, M. S.: "Soy and cardiovascular disease: cholesterol lowering and beyond". J. Nutr. 2000; 130(3): 662S-3S.

Arjmandi, B.H., Alekel, L., Hollis, B.W., et al.: "Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis". J. Nutr. 1996; 126:161-167.

Arjmandi, B.H., Birnbaum, R., Goyal, N.V., et al.: "Bone-sparing effect of soy protein in ovarian hormone-deficient rats is related to its isoflavone content". Am. J. Clin. Nutr. 1998; 68(suppl):1364S-1368S. Atkinson, C. et al: The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2004; 79:326-33, USA 2004 http://www.ajcn.org/cgi/content/full/79/2/326

Balmir, F., Staack, R., Jeffrey, E., et al.: "An extract of soy flour influences serum cholesterol and thyroid hormones in rats and hamsters". J. Nutr. 1996; 126:3046-3053.

Barnes, S., Kim, H., et al.: "Beyond ERalpha and ERbeta: estrogen receptor binding is only part of the isoflavone story". J. Nutr. 2000; 130(3): 656S-7S. Barnes S.: "The chemopreventive properties of soy isoflavonoids in animal models of breast cancer". Breast Cancer Res. Treat. 1997; 46:169-179.

Baum, J.A., Teng, H., Erdman, J.W. Jr., et. al.: "Long-term intake of soy protein improves blood lipid profiles and increases mononuclear cell low-density-lipoprotein receptor messenger RNA in hypercholesterolemic, postmenopausal women". Am. J. Clin. Nutr. 1998; 68:545-551.

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Breslau NA, Brinkley L, Hill KD, Pak CYC. Relationship of animal protein-rich diet to kidney stone formation and calcium metabolism. J.Clin Endocrinol Metab 1988;66:140-146.

Burke, G. L., Vitolins, M.Z., et al.: "Soybean isoflavones as an alternative to traditional hormone replacement therapy: are we there yet?" J. Nutr. 2000; 130(3): 664S-5S.

Bylund, A., Zhang, J. X., et al.: "Rye bran and soy protein delay growth and increase apoptosis of human LNCaP prostate adenocarcinoma in nude mice". Prostate 2000; 42(4): 304-314.

Clarkson, T. B.: "Soy phytoestrogens: what will be their role in postmenopausal hormone replacement therapy?" Menopause 2000; 7(2): 71-5.

Cline, J.M., Paschold, J.C., Anthony, M.S., et. al.: "Effects of hormonal therapies and dietary soy phytoestrogens on vaginal cytology in surgically postmenopausal macaques". Fertil Steril 1996; 65:1031-1035.

Cohen, L. A., Zhao, Z., et al.: "Effect of intact and isoflavone-depleted soy protein on NMU-induced rat mammary tumorigenesis". Carcinogenesis 2000; 21(5): 929-35.

Crouse, J.R. III., Morgan, T.M., Terry, J.G., et. al.: "A randomized trial comparing the effect of casein with that of soy protein containing varying amounts of isoflavones on plasma concentrations of lipids and lipoproteins". Arch. Intern Med. 1999; 159:2070-2076.

Duncan, A. M., Merz-Demlow, B.E., et al.: "Premenopausal equol excretors show plasma hormone profiles associated with lowered risk of breast cancer". Cancer Epidemiology, Biomarkers & Prevention 2000; 9.Juni: 581-586.

Erdman, J.W., Jr.: "Soy protein and cardiovascular disease: A statement for healthcare professionals from the nutrition committee of the AHA". Circulation 2000; 102(20):2555-9.

Foth, D., Cline, J.M.: "Effects of mammalian and plant estrogens on mammary glands and uteri of macaques". Am. J. Clin. Nutr. 1998; 68(suppl):1413S-1417S.

Figtree, G. A., Griffiths, H. et al.: "Plant-derived estrogens relax coronary arteries in vitro by a calcium antagonistic mechanism". J. Am. Coll. Cardiol. 2000; 35(7): 1977-85.

Folkman, J.: "Clinical applications of research on angiogenesis". N. Engl. J. Med. 1995; 333:1757-1763.

Fotsis, T., Pepper, M., Adlercreutz, H, et al.: "Genistein, a dietary-derived inhibitor of in vitro angiogenesis". Proc. Natl. Acad. Sci. USA 1993; 90:2690-2694.

Geller, J., Sionit, L., Partido, C., et al.: "Genistein inhibits the growth of human-patient BPH and prostate cancer in histoculture". Prostate 1998; 34:75-79.

Greaves, K.A., Parks, J.S., Williams, J.K., Wagner, J.D.: "Intact dietary soy protein, but not adding an isoflavone-rich soy extract to casein, improves plasma lipids in ovariectomized cynomolgus monkeys". J. Nutr. 1999; 129:1585-1592.

Greaves KA, Wilson, M.D., Rudel, L.L., et al.: "Consumption of soy protein reduces cholesterol absorption compared to casein protein alone or supplemented with an isoflavone extract or conjugated equine estrogen in ovariectomized cynomolgus monkeys". J. Nutr 2000; 130:820-826.

Hakkak, R., Korourian, S., et al.: "Diets containing whey proteins or soy protein isolate protect against 7,12-dimethylbenz(a)anthracene-induced mammary tumors in female rats". Cancer Epidemiol Biomarkers Prev. 2000; 9(1):113-7.

Henley, E.C., Kuster, J.M.: "Protein quality evaluation by protein digestibility-corrected amino acid scoring". Food Tech 1994; 48:74-77.

Honore, E.K., Williams, J.K., Anthony, M.S., Clarkson, T.B.: "Soy isoflavones enhance coronary vascular reactivity in atherosclerotic female macaques". Fertil Steril 1997;67:148-154.

Jenkins, D.J.A., Kendall, C.W.C., Garsetti, M., et al.: "Effect of soy protein foods on low-density lipoprotein oxidation and ex vivo sex hormone receptor activity - a controlled crossover trail. Metabolism 2000; 49(4):537-543.

Jenkins, D.J.A., Kendall, C.W.C., Vidgen, E., et al.: "The effect of serum lipids and oxidized low-density lipoprotein of supplementing self-selected low-fat diets with soluble-fiber, soy, and vegetable protein foods". Metabolism 2000; 49(1):67-72.

Kapiotis, S., Hermann, M., Held, I., et al.: "Genistein, the dietary-derived angiogenesis inhibitor, prevents LDL oxidation and protects endothelial cells from damage by atherogenic LDL". Arterioscler. Thromb. Vasc. Biol. 1997; 17:2868-2874.

Knight, D.C., Eden, J.A.: "Phytoestrogens-a short review". Maturitas 1995; 22:167-175.

Kotsopoulos, D., Dalais, F.S., et al. "The effects of soy protein containing phytoestrogens on menopausal symptoms in postmenopausal women". Climacteric 2000; (3):161-167.

Kritchevsky, D.: "Dietary protein and experimental atherosclerosis". Ann. N.Y. Acad. Sci. 1993; 676:180-187.

Kuiper, G.G., Carlsson, B., Grandien, K., et al.: "Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta". Endocrinology 1997; 138:863-870.

Kurzer, M. S.: "Hormonal effects of soy isoflavones: studies in premenopausal and postmenopausal women". J. Nutr. 2000; 130(3): 660S-1S.

Lamartiniere, C.A.: "Protection against breast cancer with genistein: a component of soy." Am. J. Clin. Nutr. Juni 2000; 71(6 Suppl): 1705f Diskussion: 1708f Department of Pharmacology and Toxicology and the Comprehensive Cancer Center, University of Alabama at Birmingham, 35294, USA.

Lamartiniere, C. A.: "Protection against breast cancer with genistein: a component of soy". Am. J. Clin. Nutr. 2000; 71(6 Suppl): 1705S-7S; 1708S-9S.

Le Marchand, L., Murphy, S.P., Hankin, J.H., Wilkens, L.R., Kolonel, L.N.: Intake of flavonoids and lung cancer. Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu 96813, USA.

Lo, G.S., Goldberg, A.P., Lim, A., et al.: "Soy fiber improves lipid and carbohydrate metabolism in primary hyperlipidemic subjects". Atherosclerosis 1986; 62:239-248.

Lovati, M.R., Manzoni, C., Canavesi, A., et. al.: "Soybean protein diet increases low density lipoprotein receptor activity in mononuclear cells from hypercholesterolemic patients". J. Clin. Invest 1987; 80:1498-1502.

Lovati, M.R., Manzoni, C., Corsini, A., et al.: "Low density lipoprotein receptor activity is modulated by soybean globulins in cell culture". J. Nutr. 1992; 122:1971-1978.

Lu, L.J., Anderson, K.E., Grady, J.J., Nagamani, M.: "Effects of soya comsumption for one month on steroid hormones in premenopausal women: implications for breast cancer risk reduction". Cancer Epidemiol. Biomark. Prev 1996; 5:63-70.

Lu, L.J., Cree, M., et al.: "Increased urinary excretion of 2-hydroxyestrone but not 16alpha-hydroxyestrone in premenopausal women during a soya diet containing isoflavones". Cancer Res. 2000; 60(5): 1299-305.

Merz-Demlow, B. E., Duncan, A.M. et al.: "Soy isoflavones improve plasma lipids in normocholesterolemic, premenopausal women". Am. J.Clin. Nutr. 2000; 71(6): 1462-1469.

Messina, M., Messina, V.: "Soyfoods, soybean isoflavones, and bone health: a brief overview." J. Ren. Nutr. 2000; 10(2): 63-8.

Messina, M., Persky, V., Setchell, K.D.R., Barnes, S.: "Soy intake and cancer risk: a review of the in vitro and in vivo data". Nutr. Cancer 1994; 21:113-131.

Nestel, P.J., Yamashita, T., Sasahara, T., et al.: "Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women". Arterioscler. Thromb. Vasc. Biol. 1997; 17:3392-3398.

Nevala, R., Vaskonen, T., et al.: "Soy based diet attenuates the development of hypertension when compared to casein based diet in spontaneously hypertensive rat". Life Sci. 2000; 66(2): 115-24.

Pan, Y., Anthony, M., et al.: "Soy phytoestrogens improve radial arm maze performance in ovariectomized retired breeder rats and do not attenuate benefits of 17beta-estradiol treatment". Menopause 2000;7(4): 230-5.

Peluso, M. R., Winters, T.A., et al.: "A Cooperative Interaction between Soy Protein and Its Isoflavone-Enriched Fraction Lowers Hepatic Lipids in Male Obese Zucker Rats and Reduces Blood Platelet Sensitivity in Male Sprague-Dawley Rats (,2)". J. Nutr 2000; 130(9): 2333-2342.

Pollard, M., Wolter, W.: "Prevention of spontaneous prostate-related cancer in Lobund-Wistar rats by a soy protein isolate/isoflavone diet". Prostate 2000; 45(2): 101-105.

Pollard, M., Wolter, W., et al.: "Prevention of induced prostate-related cancer by soy protein isolate/isoflavone-supplemented diet in Lobund-Wistar rats". In Vivo 2000; 14(3): 389-92.

Potter, S.M., Bakhit, R.M., Essex-Sorlie, D.L., et al.: "Depression of plasma cholesterol in men by consumption of baked products containing soy protein". Am J. Clin. Nutr. 1993; 58:501-506.

Potter, S.M., Jimenez-Flores, R., Pollack, J., et al.: "Protein-saponin interaction and its influence on blood lipids". J. Agric. Food Chem. 1993; 41:1287-1291.

Potter, S.M., Baum, J.A., Teng, H., et al.: "Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women". Am. J. Clin. Nutr. 1998; 68(suppl):1375S-1379S.

Potter, S.M.: "Soy protein and cardiovascular disease: the impact of bioactive components in soy". Nutr. Rev. 1998; 56:231-235.

Potter, S.M.: "Overview of proposed mechanisms for the hypocholesterolemic effect of soy". J. Nutr. 1995; 125(suppl):606S-611S.

Potter, S.M.: "Soy - new health benefits associated with an ancient food". Nutrition Today 2000; 35(2): 53-60.

Raaij, J.M.A., van, Katan, M.B., Hautvast, J.G.A.J., Hermus, R.J.J.: "Effects of casein versus soy protein diets on serum cholesterol and lipoproteins in young healthy volunteers". Am. J. Clin. Nutr. 1981; 34:1261-1271.

Raines, E.W., Ross, R.: "Biology of atherosclerotic plaque formation: possible role of growth factors in lesion development and the potential impact of soy." J. Nutr. 1995; 125(suppl):624S-630S.

Roy, D.M., Schneeman, B.O.: "Effect of soy protein, casein and trypsin inhibitor on cholesterol, bile acids and pancreatic enzymes in mice". J. Nutr. 1981; 111:878-885.

Sanchez, A., Hubbard, R.W.: " Plasma amino acids and the insulin/glucagon ratio as an explanation for the dietary protein modulation of atherosclerosis". Med. Hypotheses 1991; 35:324-329.

Setchell, K. D.: "Absorption and metabolism of soy isoflavones-from food to dietary supplements and adults to infants". J. Nutr 2000; 130(3): 654S-5S.

Shelnutt, S. R., Cimino, C.O., et al.: "Urinary pharmacokinetics of the glucuronide and sulfate conjugates of genistein and daidzein". Cancer Epidemiol Biomarkers Prev. 2000; 9(4): 413-9.

Sirtori, C.R., Lovati, M.R., Manzoni, C., et al.: "Soy and cholesterol reduction: clinical experience". J. Nutr. 1995; 125(suppl):598S-605S.

St. Germain, A., Peterson, C.T., et al.: "Isoflavone-rich or isoflavone-poor soy protein does not reduce menopausal symptoms during 24 weeks of treatment". Menopause 2001; 8(1): 17-26.

Teede, H. J. et al: Isoflavones reduce arterial Stiffness: a placebo-controlled study in men and postmenopausal women. Arterioscler Thromb Vasc Biol. 2003 Jun; 1; 23 (6): 1066-71 http://atub.ahajournals.org/cgi/content/full/23/6/1066

Teixeira, S. R., Potter, S.M., et al.: "Effects of feeding 4 levels of soy protein for 3 and 6 wk on blood lipids and apolipoproteins in moderately hypercholesterolemic men". Am. J.Clin. Nutr. 2000; 71(5): 1077-84.

Tikkanen, M. J., Adlercreutz, H.: "Dietary soy-derived isoflavone phytoestrogens. Could they have a role in coronary heart disease prevention?" Biochem. Pharmacol 2000; 60(1): 1-5.

Tsai, A.C., Mott, E.L., Owen, G.M., et al.: "Effects of soy polysaccharide on gastroinestinal functions, nutrient balance, steroid excretions, glucose tolerance, serum lipids, and other parameters in humans". Am. J. Clin. Nutr. 1983; 38:504-511.

Wagner, J.D., Cefalu, W.T., Anthony, M.S., et al.: "Dietary soy protein and estrogen replacement therapy improve cardiovascular risk factors and decrease aortic cholesteryl ester content in ovariectomized cynomolgus monkeys". Metabolism 1997; 46:698-705.

Wangen, K. E., Duncan, A.M., et al.: "Effects of soy isoflavones on markers of bone turnover in premenopausal and postmenopausal women". J. Clin. Endocrinol. Metab. 2000; 85(9): 3043-8.

Wangen, K. E., Duncan, A. M., et al.: "Soy isoflavones improve plasma lipids in normocholesterolemic and mildly hypercholesterolemic postmenopausal women". Am. J. Clin. Nutr. 2001; 73(2): 225-231.

Washburn, S., Burke, G.L., Morgan, T., Anthony, M.: "Effect of soy protein supplementation on serum lipoproteins, blood pressure, and menopausal symptoms in perimenopausal women". Menopause 1999; 6:7-13. INCLUDEPICTURE \d "/images/shim.gif" Xu, X., Duncan, A.M., et al.: "Soy consumption alters endogenous estrogen metabolism in postmenopausal women". Cancer Epidemiol. Biomarkers Prev. 2000; 9(8): 781-6.

Zava, D.T., Duwe,G.: "Estrogenic and antiproliferative properties of genistein and other flavonoids in human breast cancer cells in vitro". Nutr. Cancer 1997; 27:31-40.

Zhang, R., Li, Y., Wang, W.: "Enhancement of immune function in mice fed high doses of soy daidzein". Nutr. Cancer 1997; 29:24-28.

Zhou, Y, Lee, A.S.: "Mechanism for the suppression of the mammalian stress response by genistein, an anticancer phytoestrogen from soy". J. Natl. Cancer Inst. 1998; 90:381-388.

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