Biskind, M.S., Martin, W.C.: The use of citrus flavonoids in infection. II. Am. Digest Dis. 22:41-45, 1955
Bracke, M.E., Depypere, H.T., Boterberg, T., et. al.: "Influence of tangeretin on tamoxifen's therapeutic benefit in mammary cancer". J. Natl Cancer Inst. 1999;91:354
Buckshee, K., Takkar, D, Aggarwal, N.: "Micronized flavonoid therapy in internal hemorrhoids of pregnancy". Int. J. Gynaecol. Obstet. 1997;57:145-151.
Cospite, M.: "Double-blind, placebo-controlled evaluation of clinical activity and safety of Daflon 500 mg in the treatment of acute hemorrhoids". Angiology. 1994; 45:566-573.
Emim, J.A., Oliveira, A.B., Lapa, A.J.: "Pharmacological evaluation of the anti-inflammatory activity of a citrus bioflavonoid, hesperidin, and the isoflavonoids, duartin and claussequinone, in rats and mice". J. Pharm. Pharmacol. 1994;46:118-122.
Galley, P., Thiollet, M.: "A double-blind, placebo-controlled trial of a new veno-active flavonoid fraction (S 5682) in the treatment of symptomatic capillary fragility". Int. Angiol. 1993;12:69-72.
Godeberge P,.: "Daflon 500 mg in the treatment of hemorrhoidal disease: a demonstrated efficacy in comparison with placebo". Angiology. 1994;45:574-578
Guilhou, J.J., Dereure, O., Marzin, L., et al.: "Efficacy of Daflon 500 mg in venous leg ulcer healing: a double-blind, randomized, controlled versus placebo trial in 107 patients". Angiology. 1997; 48:77-85.
Guilhou, J.J., Fevrier, F., Debure, C., et al.: "Benefit of a 2-month treatment with a micronized, purified flavonoidic fraction on venous ulcer healing. A randomized, double-blind, controlled versus placebo trial". Int. J. Microcirc. Clin. Exp. 1997; 17(Suppl 1):21-26.
Ho, Y.H., Tan, M., Seow-Choen, F.: "Micronized purified flavonidic fraction compared favorably with rubber band ligation and fiber alone in the management of bleeding hemorrhoids: randomized controlled trial". Dis. Colon Rectum. 2000;43:66-69.
Ihme, N., Kiesewetter, H., Jung, F., et al.: "Leg oedema protection from a buckwheat herb tea in patients with chronic venous insufficiency: a single-centre, randomised, double-blind, placebo-controlled clinical trial". Eur. J. Clin. Pharmacol. 1996;50:443-447.
Lee, S.H., Park, Y.B., Bae, K.H., et al.: "Cholesterol-lowering activity of naringenin via inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase and acyl coenzyme A: cholesterol acyltransferase in rats". Ann. Nutr. Metab. 1999;43:173-180.
Manuel y Keenoy, B., Vertommen, J., De Leeuw, I.: "The effect of flavonoid treatment on the glycation and antioxidant status in Type 1 diabetic patients". Diabetes Nutr. Metab. 1999; 12:256-263.
Meyer, O.C.: "Safety and security of Daflon 500 mg in venous insufficiency and in hemorrhoidal disease". Angiology. 1994;45:579-584.
Middleton, E. Jr., Drzewiecki, G., Tatum, J.: "The effects of citrus flavonoids on human basophil and neutrophil function". Planta Med. 1987; 53:325-328.
Miller, M.J.: "Injuries to athletes. Evaluation of ascorbic acid and water soluble citrus bioflavonoids in the prophylaxis of injuries in athletes". Med Times. 1960; 88:313-316.
Misra, M.C., Parshad, R.: "Randomized clinical trial of micronized flavonoids in the early control of bleeding from acute internal haemorrhoids". Br. J. Surg. 2000; 87:868-872.
Pecking, A.P., Fevrier, B., Wargon, C., et al.: "Efficacy of Daflon 500 mg in the treatment of lymphedema (secondary to conventional therapy of breast cancer)". Angiology. 1997;48:93-98.
Platt, D., Raz, A.: "Modulation of the lung colonization of B16-F1 melanoma cells by citrus pectin". J. Natl. Cancer Inst. März 1992, 84(6):438-42 Cancer Metastasis Program, Michigan Cancer Foundation, Detroit 48201-1379.
Ross, S.A., Ziska D.S., Zhoa, K., et. al.: "Variance of common flavonoids by brand of grapefruit juice". Fitoterapia. 2000;71:154-161.
Shin, Y.W., Bok, S.H., Jeong, T.S., et al.: "Hypocholesterolemic effect of naringin associated with hepatic cholesterol regulating enzyme changes in rats". Int. J. Vitam. Nutr. Res. 1999;69:341-347.
So, F.V., Guthrie, N., Chambers, A.F., Moussa, M., Carroll, K.K: "Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices". Nutr. Cancer 1996;26(2):167-81 Department of Pharmacology and Toxicology, University of Western Ontario, London, Canada.
Strick, R., Strissel, P.L., Borgers, S., et. al.: "Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia". Proc. Natl. Acad. Sci. 2000; 97:4790-4795.
Thanapongsathorn, W., Vajrabukka, T.: "Clinical trial of oral diosmin (Daflon(r)) in the treatment of hemorrhoids". Dis. Colon Rectum. 1992;35:1085-1088.
Tsouderos, Y.: "Venous tone: are the phlebotonic properties predictive of a therapeutic benefit? A comprehensive view of our experience with Daflon 500 mg". Z. Kardiol. 1991;80(suppl 7):95-101.


